Vitamins D3 and K2 are two fat-soluble vitamins with different functions in the body. Vitamin D contributes to the maintenance of normal bones and normal muscle function, as well as normal blood calcium levels, while vitamin K contributes to the maintenance of normal bones and normal blood clotting. For this reason, some food supplements contain vitamins D3 and K2 together in the same formula.
There is no single answer to the question of how to take vitamin D3 K2 that applies to everyone. Particularly with liquid or drop-form supplements, the recommended amount may vary depending on the concentration of the vitamins in the product. For this reason, the serving size and directions for use provided on the product packaging should be followed first. Factors such as age, diet, blood test results, medication use and existing health conditions may also be relevant when assessing individual vitamin requirements.
D3 is a form of vitamin D known as cholecalciferol. Vitamin D supplements may generally contain either vitamin D2 or D3. Both forms can contribute to increasing vitamin D levels in the blood. When choosing a supplement, it is therefore important to check which form of vitamin D it contains and in what amount.
The main functions of vitamin D in the body include contributing to:
The maintenance of normal bones and teeth,
The maintenance of normal muscle function,
The maintenance of normal blood calcium levels,
The normal absorption and utilisation of calcium and phosphorus,
The normal function of the immune system.
Vitamin K contributes to normal blood clotting and the maintenance of normal bones.
Although D3 and K2 are both vitamins, they have different functions in the body. Vitamin D contributes to the normal absorption and utilisation of calcium and phosphorus, while vitamin K contributes to the maintenance of normal bones and normal blood clotting. Because of these different but related functions, some food supplements combine D3 and K2 in the same product.
However, the fact that D3 and K2 are available together in one product does not mean that everyone needs to take them together. Vitamin D requirements can vary depending on factors such as diet, sun exposure, age, blood vitamin D levels and overall health. The use of supplements containing K2 should also be considered carefully, particularly by people taking medicines that affect blood clotting.
Claims suggesting that taking D3 and K2 together “directs calcium directly to the bones” or “definitively prevents calcium from building up in the arteries” should also be treated with caution. Research into the potential effects of different forms of vitamin K2 on vascular calcification is ongoing, and current evidence does not establish a definitive clinical outcome that applies to everyone.
The main difference between vitamin D3 and D3-K2 products is their composition. D3 products contain vitamin D3 alone, whereas D3-K2 products contain vitamin K2 in addition to vitamin D3. Other characteristics, such as the amount of vitamin provided per drop, the carrier oil used and the intended user group, may also vary between products.
|
Label information |
Vitamin D3 Drops |
Vitamin D3 & K2 Drops |
|
Active ingredients |
Cholecalciferol (D3) |
Cholecalciferol (D3) and menaquinones (K2) |
|
D3 per drop |
10 µg, equivalent to 400 IU |
25 µg, equivalent to 1,000 IU |
|
Vitamin K per drop |
None |
12 µg |
|
Carrier |
Extra virgin olive oil |
Extra virgin olive oil |
|
Points to consider when choosing |
D3 amount and intended user group |
D3 and K2 amounts, medication use and intended user group |
The amounts shown in the table are based on the current information provided on İlaçsız Yaşam's product pages. As product formulations and directions for use may change over time, the information provided on the packaging of the product purchased should always take priority.
When choosing a D3 or D3-K2 supplement, it is not enough to consider whether it contains K2. The amount of vitamin per drop, recommended daily serving, intended age group and total vitamin D intake from other supplements should also be taken into account. If you take regular medication or have a specific health condition, the advice of a healthcare professional should also be considered.
Vitamins D3 and K2 are fat-soluble vitamins. The absorption of vitamin D may increase when fat is present in the intestine. However, vitamin D can still be absorbed to some extent when taken with meals that contain little or no fat. Therefore, unless the product label states otherwise, taking a D3 K2 supplement with a meal containing some fat may be preferred.[1]
In drop-form products containing a fat-based carrier such as olive oil, the vitamins are already present in an oily environment. However, this does not mean that the recommended number of drops should be changed. The amount used should always follow the serving size stated on the product label.
There is no general rule requiring vitamin D3 K2 to be taken specifically in the morning or evening. Choosing a time that is easy to incorporate into your daily routine may make regular use easier. If the manufacturer provides specific directions or a healthcare professional has recommended an individual schedule, those instructions should be followed.
Vitamin K plays a role in normal blood clotting. For this reason, people taking medicines that prevent or affect blood clotting should consult their doctor before using supplements containing K2. In people taking these medicines, sudden changes in vitamin K intake may affect how the medication works.[2]
The following groups should particularly consult a doctor or pharmacist before using a D3 K2 supplement:
People taking blood thinners or medicines that affect blood clotting,
People taking thiazide diuretics or other medicines regularly,
People with kidney disease, high blood calcium levels or parathyroid disorders,
People with a health condition that affects fat absorption,
Pregnant or breastfeeding women,
Children and adolescents,
People taking more than one vitamin D-containing supplement at the same time,
People planning to take high amounts of vitamin D or use it for a prolonged period.
Blood levels of 25-hydroxyvitamin D may be used to assess vitamin D status. However, deciding how much vitamin D should be taken based on an individual test result should be done with the guidance of a healthcare professional. Excessive vitamin D intake can increase calcium levels in the blood and urine. In more severe cases, high calcium levels may have adverse effects on the kidneys and heart.
To store D3 K2 drops appropriately, the instructions provided on the product packaging should be followed first. İlaçsız Yaşam D3-K2 is recommended to be stored in a cool, dry place at room temperature between 15–25°C.
When using supplements in drop form, the following points may also be considered:
Keep the bottle away from direct sunlight and sources of heat.
Close the bottle tightly after use.
Avoid allowing the dropper to come into contact with the mouth, tongue or other surfaces.
Keep the product out of the reach of children.
Check the recommended expiry date and any specific storage instructions that apply after opening.
If the storage instructions on the packaging differ from general recommendations, always follow the information provided on the product packaging.
Vitamins D3 and K2 are fat-soluble vitamins. Unless the product label specifies otherwise, taking them with a meal containing some fat may be preferred. However, the product's own directions and the advice of a healthcare professional should take priority for individual use.
There is no mandatory time of day when D3 K2 vitamins must be taken. A time that fits easily into your daily routine can be chosen. If your doctor has recommended a specific time, you should follow that advice.
Vitamins D3 and K2 can be taken as separate supplements or together in the same product. When using separate products, it is important to keep track of the total daily amount received from both. The appropriate option should be considered based on individual needs, diet and medication use.
D3 K2 supplements should not automatically be considered suitable for everyone. In particular, people taking anticoagulants should not use supplements containing K2 without consulting a healthcare professional. Expert advice is also recommended before use during pregnancy or breastfeeding, in children, or for people with chronic health conditions or regular medication use.
The recommended daily amount should not be exceeded to make up for a missed serving. In such cases, follow the product's directions for use. If you are unsure how to continue, consult a doctor or pharmacist.
Information: This content is provided for general informational purposes only and does not constitute medical diagnosis, treatment or personalised dosage advice. Food supplements should not be used as a substitute for a balanced and varied diet. If you take regular medication or have a specific health condition, consult a healthcare professional before using supplements.
[1] NIH Office of Dietary Supplements, Vitamin D – Health Professional Fact Sheet
https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
[2] NIH Office of Dietary Supplements, Vitamin K – Health Professional Fact Sheet
https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
